APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.

TitleAPOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.
Publication TypeJournal Article
Year of Publication2017
AuthorsQian, J., Wolters, F. J., Beiser, A., Haan, M., Ikram, A. M., Karlawish, J., Langbaum, J. B., Neuhaus, J. M., Reiman, E. M., Roberts, J. S., Seshadri, S., Tariot, P. N., Woods, B. M. C., Betensky, R. A., & Blacker, D.
JournalPLoS medicine
Volume14
Issue3
Paginatione1002254
Date Published2017 Mar
ISSN1549-1676
KeywordsAged, Apolipoproteins E, Cognitive Dysfunction, Cohort Studies, Dementia, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Netherlands, Risk Factors, United States
Abstract

With the onset of prevention trials for individuals at high risk for Alzheimer disease, there is increasing need for accurate risk prediction to inform study design and enrollment, but available risk estimates are limited. We developed risk estimates for the incidence of mild cognitive impairment (MCI) or dementia among cognitively unimpaired individuals by APOE-e4 dose for the genetic disclosure process of the Alzheimer's Prevention Initiative Generation Study, a prevention trial in cognitively unimpaired APOE-e4/e4 homozygote individuals.

DOI10.1371/journal.pmed.1002254
Alternate JournalPLoS Med.