Comparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer's disease

TitleComparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer's disease
Publication TypeJournal Article
Year of Publication2008
AuthorsCassidy, M. R., Roberts, J. S., Bird, T. D., Steinbart, E. J., Cupples, A. L., Chen, C. A., Linnenbringer, E., & Green, R. C.
JournalAlzheimer's & Dementia : the journal of the Alzheimer's Association
Volume4
Issue6
Pagination406-13
Date Published2008 Nov
ISSN1552-5279
KeywordsAlleles, Alzheimer Disease, Apolipoprotein E4, Follow-Up Studies, Genetic Counseling, Genetic Predisposition to Disease, Genetic Testing, Genotype, Humans, Linear Models, Pedigree, Presenilins, Questionnaires, Risk Factors, Stress, Psychological, Washington
Abstract

Genetic risk for Alzheimer's disease (AD) can be conferred by the susceptibility polymorphism apolipoprotein E (APOE), where the epsilon 4 allele increases the risk of developing late-onset AD but is not a definitive predictor of the disease, or by autosomal dominant mutations (eg, the presenilins), which almost inevitably result in early-onset familial AD. The purpose of this study was to compare the psychological impact of using these two different types of genetic information to disclose genetic risk for AD to family members of affected patients.

Alternate JournalAlzheimers Dement