Disclosing the disclosure: factors associated with communicating the results of genetic susceptibility testing for Alzheimer's disease

TitleDisclosing the disclosure: factors associated with communicating the results of genetic susceptibility testing for Alzheimer's disease
Publication TypeJournal Article
Year of Publication2009
AuthorsAshida, S., Koehly, L. M., Roberts, J. S., Chen, C. A., Hiraki, S., & Green, R. C.
JournalJournal of health communication
Volume14
Issue8
Pagination768-84
Date Published2009 Dec
ISSN1087-0415
KeywordsAdult, Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Female, Genetic Predisposition to Disease, Genetic Testing, Humans, Male, Middle Aged, Self Disclosure
Abstract

This study explored the extent to which recipients of genetic susceptibility testing for Alzheimer's disease (AD) communicated their results to others. It also examined demographic characteristics, along with beliefs about AD, associated with such communication. Participants (N = 271) in a randomized clinical trial involving genetic testing for Apolipoprotein E (APOE) gene variants among first-degree relatives of AD patients reported their communication behaviors 6 weeks after the results disclosure. Information on beliefs about AD and genetic testing was collected at baseline. Eighty-two percent of participants receiving APOE genotype information shared their results with someone. Specifically, 64% shared with family members, 51% with spouse or significant others, 35% with friends, and 12% with health care professionals. Greater AD treatment optimism was associated with communicating results to family (OR = 1.43), spouse (OR = 1.62), friends (OR = 1.81), and health care professionals (OR = 2.20). Lower perceived risk (OR = 0.98) and higher perceived importance of genetics in the development of AD (OR = 1.93) were associated with results communication in general. Lower perceived drawbacks of AD genetic testing was associated with results communication to friends (OR = 0.65). Beliefs about AD risks and causes, genetic testing, and development of treatments partly may determine the interpersonal communication patterns of genetic susceptibility test results.

Alternate JournalJ Health Commun