Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.

TitleDisclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.
Publication TypeJournal Article
Year of Publication2016
AuthorsChristensen, K. D., Roberts, J. S., Whitehouse, P. J., Royal, C. D. M., Obisesan, T. O., Cupples, A. L., Vernarelli, J. A., Bhatt, D. L., Linnenbringer, E., Butson, M. B., Fasaye, G. - A., Uhlmann, W. R., Hiraki, S., Wang, N., Cook-Deegan, R., & Green, R. C.
Corporate AuthorsREVEAL Study Group*
JournalAnnals of internal medicine
Volume164
Issue3
Pagination155-63
Date Published2016 Feb 02
ISSN1539-3704
KeywordsAdult, Aged, Aged, 80 and over, Alzheimer Disease, Anxiety, Apolipoprotein E4, Coronary Artery Disease, Depression, Female, Genetic Predisposition to Disease, Genotype, Health Behavior, Humans, Male, Middle Aged, Risk Assessment, Stress, Psychological, Young Adult
Abstract

Increasing use of genetic testing raises questions about disclosing secondary findings, including pleiotropic information.

DOI10.7326/M15-0187
Alternate JournalAnn. Intern. Med.