Genetic risk assessment for adult children of people with Alzheimer's disease: the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) study

TitleGenetic risk assessment for adult children of people with Alzheimer's disease: the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) study
Publication TypeJournal Article
Year of Publication2005
AuthorsRoberts, J. S., Cupples, A. L., Relkin, N. R., Whitehouse, P. J., & Green, R. C.
Corporate AuthorsREVEAL(Risk Evaluation and Education for Alzheimer's Disease) Study Group
JournalJournal of geriatric psychiatry and neurology
Volume18
Issue4
Pagination250-5
Date Published2005 Dec
ISSN0891-9887
KeywordsAge of Onset, Alzheimer Disease, Apolipoproteins E, Female, Genetic Counseling, Genetic Predisposition to Disease, Health Behavior, Humans, Insurance, Health, Male, Middle Aged, Pedigree, Risk Assessment, Stress, Psychological, Truth Disclosure
Abstract

As genetic risk factors continue to be identified for common, complex adult-onset diseases, it will become increasingly important to understand if, how, and when to translate these discoveries into clinical practice. This article provides an overview of and results to date from the REVEAL study, a multisite randomized clinical trial (n = 162) examining the impact of a genetic risk assessment program, including apolipoprotein E genotype disclosure, for adult children of people with Alzheimer's disease. The study's rationale and procedures are described, including the generation of numerical lifetime risk curves for use in the education and counseling protocol. Findings are summarized across numerous study questions, including (1) who seeks genetic risk assessment and why, (2) how apolipoprotein E results affect risk perceptions, (3) the psychological impact of genetic risk assessment, and (4) how risk information affects participants' subsequent health and insurance behaviors.

Alternate JournalJ Geriatr Psychiatry Neurol