The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine

TitleThe MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine
Publication TypeJournal Article
Year of Publication2014
AuthorsVassy, J. L., Lautenbach, D. M., McLaughlin, H. M., Kong, S. W., Christensen, K. D., Krier, J., Kohane, I. S., Feuerman, L. Z., Blumenthal-Barby, J., Roberts, J. S., Lehmann, L. S., Ho, C. Y., Ubel, P. A., MacRae, C. A., Seidman, C. E., Murray, M. F., McGuire, A. L., Rehm, H. L., & Green, R. C.
Corporate AuthorsMedSeq Project
JournalTrials
Volume15
Pagination85
Date Published2014
ISSN1745-6215
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Attitude of Health Personnel, Cardiomyopathies, Clinical Competence, Curriculum, Education, Medical, Continuing, Female, Genetic Counseling, Genetic Predisposition to Disease, Genetic Testing, Genome, Human, Health Knowledge, Attitudes, Practice, Humans, Inservice Training, Male, Middle Aged, Phenotype, Predictive Value of Tests, Primary Health Care, Prognosis, Research Design, Sequence Analysis, DNA, Young Adult
Abstract

Whole genome sequencing (WGS) is already being used in certain clinical and research settings, but its impact on patient well-being, health-care utilization, and clinical decision-making remains largely unstudied. It is also unknown how best to communicate sequencing results to physicians and patients to improve health. We describe the design of the MedSeq Project: the first randomized trials of WGS in clinical care.

DOI10.1186/1745-6215-15-85
Alternate JournalTrials