Disclosure of APOE genotype for risk of Alzheimer's disease

TitleDisclosure of APOE genotype for risk of Alzheimer's disease
Publication TypeJournal Article
Year of Publication2009
AuthorsGreen, R. C., Roberts, J. S., Cupples, A. L., Relkin, N. R., Whitehouse, P. J., Brown, T., Eckert, S. L. R., Butson, M., Sadovnick, D. A., Quaid, K. A., Chen, C., Cook-Deegan, R., & Farrer, L. A.
Corporate AuthorsREVEAL Study Group
JournalThe New England journal of medicine
Date Published2009 Jul 16
KeywordsAdult, Aged, Alzheimer Disease, Anxiety, Apolipoprotein E4, Chi-Square Distribution, Depression, Female, Genetic Counseling, Genetic Predisposition to Disease, Genetic Testing, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Prospective Studies, Truth Disclosure

The apolipoprotein E (APOE) genotype provides information on the risk of Alzheimer's disease, but the genotyping of patients and their family members has been discouraged. We examined the effect of genotype disclosure in a prospective, randomized, controlled trial.

Alternate JournalN. Engl. J. Med.